The cause of his death is unknown. Some scholars have suggested that the signatures on his will indicate that he was already sick at the date of signing, March, 25, 1616.
Shakespeare was buried on April 25, 1616 in Holy Trinity Church, Stratford, where he had been baptised just over 52 years earlier. His tomb, which lies beneath the floor of the church inside the chancel rail, is covered by a stone inscribed with a curse :
Good friend for Jesus sake forbearTo dig the dust enclosed here!Blest be the man that spares these stones,And curst be he that moves my bones.

Timeline of Shakespeare's Life

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Shakespear's Early life

William Shakespeare was born in April of 1564 in Stratford-upon-Avon, Warwickshire. This was an important agricultural center in the 16th century and not to far west of London. It is said that he was born on April 23, also the day he died 52 years later although there's no record of the actual day he was born. He was Baptised a few days later on April 26. William was the third child and the first son of his parents John and Mary Shakespeare. His father was a whittawer, someone that works with leather and became an important person in the government by working his way up from a member of council to the high Bailiff. William's Mother Mary had 7 other children with John Shakespeare. Growing up it is believed that William Shakespeare went to school at a place called Stratford Grammar school, but there isn't any record of it like many things about Shakespeare's life. William got married to Anne Hathaway in 1582 on November 28th. Anne was 8 years older than William and her father was a farmer. The only thing that William Shakespeare left behind for his wife in his will was his second best bed. William and Anne had three children. On May 26th in their first child, Susanna was baptised. Two years after Susanna was born they had twins named Hamnet and Judith. After that there is no record of William Shakespeare's life giving that time the name of "the lost years".

Shakespeare was born in April, 1564 in Stratford, Warwickshire. He was born in the house of John Shakespeare. William was the third child out of his eight siblings and was the first boy. They were all born in this house; and spent their childhood years in this house. On April 26, Shakespeare was baptized at the Trinity church. William died on April 23, 1616, due to unknown causes. Shakespeare was buried on April 25, 1616 in the place he was baptized over 52 years before. Shakespeare published a will in January, In the year of 1616. Included in his will was giving 10 pounds to the poor in Stratford.